导师资格：博士生导师

所在教研室/单位： 生理学教研室

E-mail：xujing68@mail.sysu.edu.cn

研究方向：神经病理性疼痛；胶质细胞；线粒体转移

个人简介

徐劲，博士，william威廉中文教授，博士生导师。博士毕业于william威廉中文，获生理学博士学位。2021年至2026年在美国杜克大学从事博士后研究，2026年由WilliamHill中文引进回国，WilliamHill中文逸仙学者。从事神经科学及神经病理性疼痛研究，以独立第一作者身份在Nature、Neuron、Pain、Anesthesiology等国际学术期刊发表多篇论文。

 

研究方向

由神经损伤、糖尿病及化疗等因素引起的神经病理性疼痛和外周神经退行性病变严重影响人类健康。胶质细胞通过多种机制支持并调控神经元功能，在疼痛信号传递与调控中发挥重要作用。我的研究重点关注胶质细胞在神经系统中的功能及其在疼痛调控中的作用。研究首次揭示了这些胶质细胞的重要保护功能：1. 在外周神经系统背根神经节中，卫星胶质细胞能够向感觉神经元转移线粒体；2. 在中枢神经系统脊髓中，发现星形胶质细胞表达的孤儿G蛋白偶联受体 GPR37L1 可以调控突触传递。这些研究揭示了外周和中枢胶质细胞此前未被充分认识的功能，为理解外周神经病变的发生机制提供了新的见解，并为神经病理性疼痛的治疗提供了新策略。

 

目前课题组主要研究：1. 神经病理性疼痛和外周神经退行性病变；2. 中枢和外周神经系统中的胶质细胞；3. 细胞间的线粒体转移及其神经调控机制。

 

代表性学术论著

  1. Jing Xu, Yize Li, Charles Novak, Min Lee, Zihan Yan, Sangsu Bang, Aidan McGinnis, Sharat Chandra, Vivian Zhang, Wei He, Terry Lechler, Maria Pia Rodriguez Salazar, Cagla Eroglu, Matthew L Becker, Dmitry Velmeshev, Richard E Cheney, and Ru-Rong Ji. Mitochondrial transfer from glia to neurons protects against peripheral neuropathy. Nature. 2025. (Highlighted in Nature Neuronscience, Satellite glia fuel up neurons.Marin IA. 2026. Cell Research, Borrowed mitochondria, spared neurons. Im GB, Melero-Martin JM.. 2026.)

  2. Jing Xu, Zihan Yan, Sangsu Bang, Dmitry Velmeshev, Ru-Rong Ji. GPR37L1 identifies spinal cord astrocytes and protects neuropathic pain after nerve injury. Neuron. 2025 Apr 16;113(8):1206-1222.e6. (Preview in Neuron, Astrocytic GPR37L1: A new guardian against the onset and chronicity of neuropathic pain. Neuron. 2025 Apr 16;113(8):1121-1123.)

  3. Jing Xu. Shaoyong Song. Ru-Rong J. Do microglia Exist in the peripheral nervous system? The Innovation. 2025. June 18. 

  4. Jing Xu, Sangsu Bang, Ouyang Chen, Yize Li, Aidan McGinnis, Qin Zhang, Ru-Rong Ji. Neuroprotectin D1 and GPR37 protect against chemotherapy-induced peripheral neuropathy and the transition from acute to chronic pain. Pharmacological Research. 2025 Jun:216:107746.

  5. Jing Xu, Aidan McGinnis, Ru-Rong Ji. Piezo2 mediates visceral mechanosensation: A new therapeutic target for gut pain? Neuron. 2023 Feb 15;111(4):450-452.

  6. Jing Xu, Xuxia Wei, Feng Gao, Xiongxiong Zhong, Ruixian Guo, Yun Ji, Xin Zhou, Jialiang Chen, Peiwen Yao, Xianguo Liu, Xuhong Wei. NADPH oxidase 2 derived ROS contributes to LTP of C-fiber evoked field potentials in spinal dorsal horn and persistent mirror-image pain following high frequency stimulus of the sciatic nerve. Pain, 2020 Apr;161(4):758-772.

  7. Jing Xu, Yi-Wei Feng, Ling Liu, Wei Wang, Xiong-Xiong Zhong, Xu-Hong Wei, Xian-Guo Liu. Liver X Receptor alpha Is Involved in Counteracting Mechanical Allodynia by Inhibiting Neuroinflammation in the Spinal Dorsal Horn. Anesthesiology. 2017 Sep;127(3):534-547.

     

其他学术论著

  1. Yize Li, Sangsu Bang, Jasmine Ji, Jing Xu, Min Lee, Sharat Chandra, Charles N Serhan, Ru-Rong Ji. Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis. J Clin Invest. 2026 Jan 16;136(2):e190754.

  2. Ran Guo, Ouyang Chen, Yang Zhou, Sangsu Bang, Sharat Chandra, Yize Li, Gang Chen, Rou-Gang Xie, Wei He, Jing Xu, Richard Zhou, Shaoyong Song, Kelsey L Person, Madelyn N Moore, Abigail R Alwin, Ivan Spasojevic, Michael R Jackson, Steven H Olson, Marc G Caron, Lauren M Slosky, William C Wetsel, Lawrence S Barak, Ru-Rong Ji. Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain. Cell. 2025 Aug 7;188(16):4332-4349.e21.

  3. Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahani, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, Ru-Rong Ji. Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis. J Clin Invest. 2024 Mar 26;134(9):e173537. doi: 10.1172/JCI173537.

  4. Thomas Buchheit, Yul Huh, Andrew Breglio, Sangsu Bang, Jing Xu, Yutaka Matsuoka, Ran Guo, Andrey Bortsov, Julio Reinecke, Peter Wehling, Tony Jun Huang, Ru-Rong Ji. Intrathecal administration of conditioned serum from different species resolves Chemotherapy-Induced neuropathic pain in mice via secretory exosomes. Brain Behav Immun. 2023 Jul:111:298-311. doi: 10.1016/j.bbi.2023.04.013. Epub 2023 May 5.

  5. Gang Chen, Jing Xu, Hao Luo, Xin Luo, Sandeep K Singh, Juan J Ramirez, Michael L James, Joseph P Mathew, Miles Berger, Cagla Eroglu, Ru-Rong Ji. Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling. JCI Insight. 2022 Dec 8;7(23):e161028. doi: 10.1172/jci.insight.161028.

 

 

招生/招聘信息：

本实验室长期招收硕士/博士研究生和博士后，欢迎具有神经科学、生物信息学等相关专业背景的同学加入！有意者请联系徐劲课题组（xujing68@mail.sysu.edu.cn）。