导师资格：硕士生导师

所在教研室/单位： 组织胚胎学教研室

E-mail：xiak7@mail.sysu.edu.cn

研究方向：干细胞与生殖医学

个人简介

WilliamHill中文副教授；2015年毕业于william威廉中文，获临床医学学士学位；2020年毕业于WilliamHill中文附属第一医院，获外科学博士学位；此后在william威廉中文开展博士后及特聘副研究员工作，2024年转聘副教授。

以通讯或第一作者（共同）在Nat Cell Biol、Nat Commun、Cell Rep Med、Cell Rep、Adv Sci、eLife、Cell Discov、Hum Reprod等刊物发表论文20篇；参与制定临床诊疗专家共识2项；中国发明专利7项，已授权2项，申请国际PCT专利1项；主持国家自然科学基金（联合重点、面上、青年）、中国博士后基金、广东省自然基金等项目。

学术成果

（# co-first author; *co-corresponding author）

  1. Xia K#, Zhang S#, Peng H#, Chen H#, Yang C, Yu J, Luo P, Lu Q, Chen H, Huang L, Xiong Y, Zhao L, Jia L, Li L, Qiu Y, Guo Y, Liu C, Fan H, Dai Z, Liu G, Ke Q, Wang T, Li W, Chen L*, Deng C*, Xiao H*, Xiang AP*.An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis. Nature Cell Biology. in press

  2. Liu C#, Peng H#, Yu J#, Luo P#, Xiong C, Chen H, Fan H, Ma Y, Ou W, Zhang S, Yang C, Zhao L, Zhang Y, Guo X, Ke Q, Wang T, Deng C, Li W, Xiang AP*, Xia K*. Impaired ketogenesis in Leydig Cells drives testicular aging. Nature Communications. 2025  Highlighted in Nature Reviews Urology https://www.nature.com/articles/s41585-025-01060-4

  3. Xia K#, Wang F#, Lai X#, Dong L#, Luo P, Zhang S, Yang C, Chen H, Ma Y, Huang W, Ou W, Li Y, Feng X, Yang B, Liu C, Lei Z, Tu X, Ke Q, Mao FF, Deng C*, Xiang AP*. AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure. Cell Reports Medicine. 2022.

  4. Yu J#, Yang C#, Guo Y#, Dai Z#, Luo P, Zhang Y, Peng H, Zhang S, Liu C, Zhao L, Fan H, Xiong Y, Xie Q, Jia L, Yu X, Wang T, Li W, Ke Q, Zheng F, Deng C*, Xiang AP*, Chen H*, Xia K*. Tracing the origin of testosterone-producing Leydig cells during postnatal development and regeneration. Cell Reports. 2025

  5. Xia K#, Wang F#, Tan Z#, Zhang S#, Lai X, Ou W, Yang C, Chen H, Peng H, Luo P, Hu A, Tu X, Wang T, Ke Q, Deng C*, Xiang AP*. Precise correction of Lhcgr mutation in stem Leydig cells by prime editing rescues hereditary primary hypogonadism in mice. Advanced Science. 2023

  6. Zhang S#, Yang B#, Shen X#, Chen H#, Wang F, Tan Z, Ou W, Yang C, Liu C, Peng H, Luo P, Lei Z, Yan S, Wang T, Ke Q, Deng C, Xiang AP*, Xia K*. AAV-mediated gene therapy restores natural fertility and improves physical function in the Lhcgr-deficient mouse model of Leydig cell failure. Cell Proliferation. 2024

  7. Xia K#, Chen H#, Wang J#, Feng X#, Gao Y, Wang Y, Deng R, Wu C, Luo P, Zhang M, Wang C, Zhang Y, Zhang Y, Liu G, Tu X, Sun X, Li W, Ke Q*, Deng C*, Xiang AP*.Restorative functions of autologous stem Leydig cell transplantation in a testosterone-deficient non-human primate model. Theranostics. 2020

  8. Chen H#, Xia K#, Huang W#, Li H, Wang C, Ma Y, Chen J, Luo P, Zheng S, Wang J, Wang Y, Dong L, Tan Z, Lai X, Mao FF, Li W, Liang X, Wang T, Xiang AP, Qiong K*.Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates. Cell Discovery. 2021

  9. Xia K#, Luo P#, Yu J#, He S#, Dong L, Gao F, Chen X, Ye Y, Gao Y, Ma Y, Yang C, Zhang Y, Yang Q, Han D, Feng X, Wan Z, Cai H, Ke Q, Wang T, Li W, Tu X, Sun X, Deng C*, Xiang AP*. Single-cell RNA Sequencing Reveals Transcriptomic Landscape and Potential Targets for Human Testicular Ageing. Human Reproduction.2024

  10. Xia K, Ma Y, Feng X, Deng R, Ke Q, Xiang AP*, Deng C*. Endosialin defines human stem Leydig cells with regenerative potential. Human Reproduction. 2020

  11. Huang X#, Xia K#, Yang M#, Hong M, Jiang M, Li W, Lei Z, Xiang AP*, Zhao W*. A single-cell atlas of the testicular interstitium defines Leydig progenitor networks sustaining Leydig cell homeostasis across the lifespan. eLife. 2025

科研项目

主持：

  1. 国家自然科学基金区域联合重点支持项目，2026-01至2029-12

  2. 国家自然科学基金面上项目，2024-01至2027-12

  3. 国家自然科学基金青年项目，2022-01至2024-12

  4. 中国博士后基金面上项目，2021-10至2022-07

  5. 广东省自然科学基金面上项目，2022-01至2024-12

  6. 广州市基础与应用基础研究“启航”类项目，2024-01至2025-12

  7. WilliamHill中文高校基本科研业务费，2024-01至2024-12

  8. WilliamHill中文高校基本科研业务费，2022-01至2022-12